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KMID : 0363820000340050371
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Korean Journal of Nuclear Medicine
2000 Volume.34 No. 5 p.371 ~ p.380
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Preoperative Evaluation of Brain Lesion with 201Tl Brain SPECT:Is It Useful to Differentiate Benign and Malignant Lesions?
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Sohn Hyung-Sun
Kim Euy-Neyng
Kim Sung-Hoon
Chung Yong-An
Chung Soo-Kyo
Hong Yong-Kil
Lee Youn-Soo
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Abstract
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Purpose: Thallim-201 () brain SPECT, which can represent cellular activity of brain lesions, may provide more useful information in differentiating between benign and malignant brain lesions more so than CT of MRI, that merely represents anatomic changes or breakdown of blood brain barrier. We used brain SPECT prospectively to evaluate the utility of -indices as an indicator of benign or malig nant lesions.
Materials and Methods: We studied 28 patients. There were 13 cases of benign lesions (3: nonspecific benign lesion, 3: meningioma, 2: low grade glioma, 1: tuberculoma, central neurocytoma, hemangioblastoma, radiation necrosis, and choroid plexus papilloma) and 15 cases of malignant lesions (6: glioblastoma multiforme, 5: anaplastic glioma, 2: medulloblastoma, 1: metastasis and lymphoma). In all patients, CT and/or MRI were obtained and then brain SPECT was obtained with measuring mean index and peak index. An unpaired t-test was performed to compare the -indices and pathologic diagnoses to evaluate the utility of -indices as all indicator of benign or malignant lesions.
Results: There were no statistically significant difference in -indices between benign and malignant brain lesion (p>0.05).
Conclusion: These results demonstrated that we could not use indices on brain SPECT alone as an indicator of benign or malignant brain lesions.
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KEYWORD
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Brain lesion differentiation, 201Tl, SPECT
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